Blinatumomab-Induced T Cell Activation at Single Cell Transcriptome Resolution
نویسندگان
چکیده
منابع مشابه
Cell lineage specification at single cell resolution.
Single cell technology has been widely used in developmental and stem cell biology. In mouse, single cell transcriptome has revealed the cell lineage specification in pre-implantation and post-implantation stage embryo. Now Mohammed et al. investigated the dynamic cell fate commitment during the transition from peri-implantation to early post-implantation stage with single cell RNA sequencing. ...
متن کاملMonitoring the T-Cell Receptor Repertoire at Single-Clone Resolution
The adaptive immune system recognizes billions of unique antigens using highly variable T-cell receptors. The alphabeta T-cell receptor repertoire includes an estimated 10(6) different rearranged beta chains per individual. This paper describes a novel micro-array based method that monitors the beta chain repertoire with a resolution of a single T-cell clone. These T-arrays are quantitative and...
متن کاملHematopoiesis at single-cell resolution.
A major aim in biomedical research is to detangle the complexity of systems that are made up of individual cells. Such work includes identification of the cells that underlie one or more defined biological responses and establishment of the developmental pathways that lead to production of the mature functional effector cells. In preclinical research, the possibility to isolate cells at defined...
متن کاملThe Epigenetic Regulation of Blinatumomab Gene Expression: Tumor Cell-dependent T cell Response against Lymphoma Cells and Cytotoxic Activity
Conventional treatment for cancer such as surgical resection and chemotherapy can cause damage in cases with advanced cancers. Moreover, the identification of tumor-specific targets has great importance in T-cell therapies. For decades, T cell activity has been stimulated to improve anti-tumor activity. Bispecific antibodies have attracted strong interest from pharmaceutical companies, for thei...
متن کاملHaplotype resolution at the single-cell level.
One of the most rapidly advancing areas in genomics in recent years has been the explosion of platforms to assess properties at the single-cell level. The driving force behind these advancements has been a renaissance of sorts in how we think about the architecture and heterogeneity present in a population of cells (1, 2). While these concepts are not new, the advancement of technologies to ass...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 2019
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2019-124636